Some drugs can cause stomach and duodenal ulcers

Some drugs can cause stomach and duodenal ulcers, which non-steroidal anti-inflammatory drugs (such as Fenbid, ibuprofen, Voltaren, etc.) the most obvious, and adrenocorticotropic hormone, reserpine and so on.

Long-term oral administration of these drugs in patients, about 10% -25% of the patients of peptic ulcer, gastric ulcer which is more common. The risk of its incidence and treatment dosage size and how long, and individual sensitivity to these drugs also have a certain relationship.

Non-steroidal anti-inflammatory drugs cause gastric damage, in addition to the direct effect of drugs on the gastric mucosa, but because these drugs inhibit the enzyme activity in vivo oxidation but also interfere with stomach, duodenal mucosal prostaglandin synthesis within the that prostaglandins decrease, weakening its gastroduodenal mucosal protection.

Long-term use can also be induced adrenocorticotropic hormone peptic ulcer, the reason may be decreased production of these drugs can make mucus, thus affecting the mucosa of the defense function. Adrenal cortex hormones can also affect the synthesis of prostaglandins, weakening of the stomach and duodenum in rats. However, there is this type of drug-induced peptic ulcer controversy.

Reserpine-like effect with histamine, can increase gastric acid secretion, and therefore, the potential role of induced ulcers.

Patients with peptic ulcer, such as non-essential treatment, for certain drugs, such as non-steroidal anti-inflammatory drugs, hormones, reserpine and other drugs should not abuse. If we must take, we should note the following:

1, the selection of toxicity of drugs and small doses, taking care to avoid the joint use of drugs prone to cause ulcers.

2, after a meal medication to reduce the direct damage of gastric mucosa.

3, which can apply some antacids, such as H2 receptor antagonists (famotidine, etc.), mercury proton inhibitors (omeprazole, etc).

4, prostaglandin E preparations to prevent a result of taking non-steroidal anti-inflammatory drugs induced ulcers, misoprostol is now used more often, according to the results of clinical reports, the best effect.

5, H. pylori-positive patients with long-term use or are planning to use non-steroidal anti-inflammatory drugs, patients need to consider anti-Helicobacter pylori eradication therapy.

6, the application of selective Cox-2 has a non-steroidal anti-inflammatory drugs on gastric damage than conventional non-steroidal anti-inflammatory drugs is less. But in recent years has been reported, these drugs have side effects on the heart, should be under the guidance of a doctor medication.