Beware! Inappropriate medication can cause stomach ulcers

Many factors that causes stomach ulcers occur, such as genetic factors, chemical factors, lifestyle factors, mental factors, infection factors, drug factors, including improper use of drugs as a result of gastric ulcers are not uncommon, it should lead to doctors, pharmacists and patients with attention . So, what are the clinical drugs can cause ulcers, how should the rational use of these drugs?

Erythromycin, penicillin, erythromycin and similar antimicrobial spectrum, mainly against Gram-positive bacteria with antibacterial properties. Clinical studies have shown that the drug can directly stimulate the gastric mucosa, on gastric mucosal damage produced so that patients, vomiting, diarrhea, abdominal pain, severe cases can lead to stomach ulcers occur.

Aspirin is commonly used in clinical anti-inflammatory drugs, but aspirin can inhibit prostaglandin synthesis, the gastric mucosal ischemia, increase in gastric acid secretion; while prostaglandin precursor arachidonic acid accumulation had local stimulus, which will increase its on gastric mucosa injury. And long-term high-dose aspirin can be induced ulcers, stomach bleeding or even cause imperceptible.

Clopidogrel bisulfate, also known as clopidogrel, for myocardial infarction, ischemic stroke, peripheral arterial disease patients and patients with acute coronary syndrome. Drug compared with aspirin, although the lower incidence of gastric ulcer, but also can lead to stomach ulcers, stomach bleeding.

Prednisone also known as prednisone, is the glucocorticoid drugs, regulate the sugar, fat, protein biosynthesis and metabolism, but also inhibit the immune response, anti-inflammatory, anti-virus, anti-shock effect. Glucocorticoid drugs can change the thickness and composition of gastric mucosa, thus weakening the self-protective effect of gastric mucosa, the mucosa vulnerable to acid erosion. At the same time, glucocorticoid drugs can inhibit gastric mucosal cell renewal, resulting in acute gastrointestinal ulcers and lead to potentially significant deterioration of chronic ulcers.

Many types of cold medicine cold medicines, but most contain phenacetin, aminopyrine, caffeine, phenobarbital and other ingredients that have some irritation of the stomach can often cause upper abdominal pain, nausea, vomiting, especially caffeine and aminopyrine greater irritation. Caffeine in addition to a direct stimulation of gastric mucosa, there to promote the role of gastric acid secretion, can stomach, duodenum inflammation and ulcers worse.

Anticancer drugs in the anticancer drugs, most drugs will cause gastrointestinal reactions, such as nausea, vomiting and other, individual drugs such as Lomustine, fluorouracil, HCFU, Doxifluridine, cytarabine, methotrexate, Ida than the magnitude, can directly stimulate the gastric mucosa, causing ulcers or bleeding.

Sulfonylurea hypoglycemic agents are the drugs glibenclamide, Gliclazide, glipizide, gliquidone, glimepiride, etc., can be excited about the vagus nerve, so that an increase in gastric acid secretion and gastric mucosal injury caused , leading to ulcers, stomach bleeding, gastric perforation.

Chinese medicine can cause stomach ulcers are expelling wind dampness, anti-inflammatory pain, the role of detoxification medicine, general irritation of the stomach and may Shang Wei. Nausea of ​​expectorants, such as the Campanulaceae, Polygala, etc., will stimulate the oral mucosa, causing mild nausea, severe cases can lead to stomach bleeding.

For these drugs, doctors prescribe to patients, pharmacists in dispensing to patients, side effects should be made clear to him, to remind the patient attention; patients taking these drugs during the event of a stomach upset, it is timely advice to doctors and pharmacists; If the symptoms are serious and should be discontinued immediately and appropriate prescription of a doctor of alternative medicine.